Biology’s Big Bang
The current issue of The Economist contains a special feature about RNA. One of the articles summarizes the recent advances that have made molecular biologists realize the significance of RNA; the other discusses Craig Venter’s recent application to patent an artificial life form.
In the editorial that accompanies the feature, an analogy is made between biology and physics. The biological sciences before the recent discoveries about RNA are likened to physics before the discovery of sub-atomic particles:
Nature is full of surprises. When atoms were first proved to exist (and that was a mere century ago), they were thought to be made only of electrons and protons. That explained a lot, but it did not quite square with other observations. Then, in 1932, James Chadwick discovered the neutron. Suddenly everything made sense - so much sense that it took only another 13 years to build an atomic bomb.
It is probably no exaggeration to say that biology is now undergoing its “neutron moment”. For more than half a century the fundamental story of living things has been a tale of the interplay between genes, in the form of DNA, and proteins, which the genes encode and which do the donkey work of keeping living organisms living. The past couple of years, however, have seen the rise and rise of a third type of molecule, called RNA.
…If RNA is controlling the complexity of the whole organism, that suggests the operating system of each cell is not only running the cell in question, but is linking up with those of the other cells when a creature is developing. To push the analogy, organs such as the brain are the result of a biological internet. If that is right, the search for the essence of humanity has been looking in the wrong genetic direction.
